Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID

Many patients with COVID-19 experience a range of debilitating symptoms months after being infected, syndrome termed long-haul COVID. A 68-year-old male presented lung opacity, fatigue, physical and cognitive weaknesses, loss smell lymphocytopenia. After rounds therapeutic plasma exchange (TPE), the patient returned to normal activities work. Mechanistically in patient’s peripheral blood mononuclear cells (PBMCs), markers inflammatory macrophages diminished lymphocytes, including natural killer (NK) cytotoxic CD8 T-cells, increased. Circulating proteins diminished, while positive regulators tissue repair This case study suggests that TPE has capacity treat COVID.